Astaxanthin: A Super Substance for Heart Health

Written by Dr. Jack Wolfson
Posted August 5, 2016

Astaxanthin is a colorful, fat-soluble pigment synthesized by algae and concentrated up the food chain by yeast, fish (salmon), and crustaceans like lobster and shrimp. It is also found in the feathers of some birds such as the flamingo. It provides the red color of salmon meat and the red color of cooked shellfish. Synthetic astaxanthin is added to feed of farm-raised fish to provide color.

Pronounce astaxanthin by using the Z sound for the X.

The part of astaxanthin that causes the color we see with our human eyes also provides a major antioxidant function. Astaxanthin is considered the most powerful natural carotenoid antioxidant, being 65 times more potent than vitamin C, 54 times more than β-carotene, 14 times more than vitamin E, and 10 times more powerful than zeaxanthin, lutein, and canthaxanthin. Astaxanthin is a cousin in the carotenoid class with beta-carotene and zeaxanthin, but unlike beta-carotene, humans cannot convert it to the active form of vitamin A.

Accumulating evidence suggests that astaxanthin could exert cardioprotective actions by improving oxidative stress, inflammation, lipid metabolism, and glucose metabolism. Let's explain this a little further...

Protect the LDLs

That's right. Protect the "bad" cholesterol. LDL is essential to human life. But we don't want our LDLs damaged. One of the steps in the progress of coronary artery disease (blockages) is damaged LDL particles. These LDLs are known as oxidized LDLs and are easily taken into immune cells inside the blood vessel wall known as macrophages. A study from 2000 found that astaxanthin protects LDL from oxidation (1).

Many studies have demonstrated the antioxidant capabilities of astaxanthin starting at a dose of 3.6mg. It takes about 6 oz. of salmon to get the 3.6 mg of astaxanthin. In obese adults, supplemental astaxanthin reduced biomarkers of oxidative stress including malondialdehyde and isoprostane, and increased superoxide dismutase and total antioxidant capacity (2). All of these actions to reduce oxidative stress will inhibit plaque formation and provide many other benefits as well.

Much publicity has been given to activators of NrF2, a master regulator of the antioxidant response and detoxification genes. Astaxanthin increases Nrf2 and liver detoxification enzymes. Combined with EPA and DHA omega-3 fish oils, glutathione levels are boosted. Glutathione is a major antioxidant (3). Other products that boost Nfr2 include green tea, turmeric, bacopa, and ashwagandha.

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Boost HDL Function

Paraoxonase 1 (PON1) is an enzyme located on HDL particles, but the enzymatic activity of PON1 is readily inactivated by oxidants. PON1 on HDL protects against LDL oxidation. In the rabbit model, astaxanthin prevented protein oxidation and changes in PON1 (4). Of note, PON1 is promoted through regular physical activity.

Speaking of physical activity, astaxanthin helps athletes with oxidative stress. Astaxanthin supplementation (4 mg/day) for 90 days showed a beneficial effect in improving PON1 activity in young soccer players (5). Mice fed astaxanthin improved their exercise performance (6).

Change Lipid Numbers

Human experiments have found that astaxanthin increases HDL, lowers triglycerides. and increases LDL receptors.(7) By increasing LDL receptors, old LDL particles can be removed from circulation. The dosing used in these studies was pretty high, upwards of 12 mg per day. However, a recent meta-analysis of seven trials did not find that astaxanthin had significant effects on lipid reduction (8).

Lower Blood Sugar and Lose Weight

As discussed above, astaxanthin decreases inflammation and oxidation, two processes that damage the body. In doing so, insulin sensitivity improves and blood sugar is reduced. Most studies are looking at the mouse model and there are only a few human trials. Obese mice fed astaxanthin readily lost weight. Another trial in rodents found that astaxanthin reduced blood pressure (9).

Boost Your Astaxanthin Intake

If you are looking to boost your levels of astaxanthin, look no further than eating plenty of wild salmon, wild shrimp, and lobster. Consider supplementation based on your cardiovascular risk factors and advance blood/urine testing. If you are concerned about heavy metals after seafood consumption, consider supplementation with chlorella during and after your meal.

Dr. Jack Wolfson

Senior Editor, Clear Health Now

Dr. Jack Wolfson DO, FACC is a board-certified cardiologist who believes bad nutrition and toxins create heart health problems. He prevents and treats cardiovascular disease with good nutrition, not medicines and treats the whole person, not just the symptoms.

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1) J Atheroscler Thromb 2000; 7(4): 216-22
2) Phytother. Res. 2011;25:1813–1818.
3) Food Chem. Toxicol. 2013;62:869–875.
4) J. Clin. Biochem. Nutr. 2012;51:42–49
5) Phytother. Res. 2013;27:1536–1542.
6) Biochem. Biophys. Res. Commun. 2008;366:892–897.
7) Atherosclerosis. 2010;209:520–523.
8) Arch Med Sci. 2015 Apr 25; 11(2): 253–266.
8) Biosci. Biotechnol. Biochem. 2007;71:893–899


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