Scientists Turn Off Cancer-Causing Genetic Mutation?

Written by Alex Reid
Posted February 8, 2021

Hi y’all!

Alex Reid here with your Monday roundup.

It almost sounds like a sci-fi movie. I’ve dreamed of flipping the “off” switch for all types of ailments.

Could you imagine a world where all disease just vanished?

No diabetes, no cancer, no Alzheimer’s disease.

That’s what I would call a utopia.

Here’s the latest to cross my desk...

Scientists have hit a milestone for cancer research.

The New York Times recently posted:

After 40 years of effort, researchers have finally succeeded in switching off one of the most common cancer-causing genetic mutations in the human body. The finding promises to improve treatment for thousands of patients with lung and colorectal cancer, and may point the way to a new generation of drugs for cancers that resist treatment.

There's one cancer drug that catches my attention. Meet sotorasib. Created by drugmaker Amgen, the company tests sotorasib in patients who have had the most common type of lung cancer: non-small cell cancer.

Here are key results on the drug’s efficacy:

On average, tumors in the patients stopped growing for seven months. In three out of 126 patients, the drug seems to have made the cancer disappear entirely, at least so far, although side effects included diarrhea, nausea, and fatigue.

This is critical news: Every year, 228,000 Americans are diagnosed with non-small cell cancer. And, unfortunately, there is no cure for most patients who are in the advanced stages.

Here’s how sotorasib works…

The drug attacks a cancer-causing mutation, known as KRAS G12C. And here are three things to know about it:

  1. KRAS G12C mutation is most common in lung cancer.
  2. It also occurs in other cancers, especially in colorectal cancer, where it is found in up to 3 percent of tumors.
  3. It occurs particularly in pancreatic cancer. KRAS mutations of some type are present in 90% of pancreatic tumors.

Frankly, I’m just getting started… Learn about how scientists found the “off” switch for this mutation by going here.

Turning “Off” the Aging Switch ?

Our very own Dr. Anil Bajnath has been researching other “off” switches, particularly one for aging.

If you care about your longevity, you can’t afford to miss this presentation.

To your health,

Alex Reid
President, Longevity Insider HQ