The "Inflammaging" Phenomenon - Part 2

Written by Anil Bajnath, MD
Posted September 24, 2020

Dear Reader,

When it comes to aging and longevity, we never stop talking about autophagy, the cellular housekeeping your body does to clear out damaged cells and make room for new ones. We already know inflammaging is a direct result of the piling up of senescent (or “zombie”) cells, triggering an immune response and causing problems over time. Initiating autophagy is one of many solutions to low-grade, chronic inflammation.

You can do this by going approximately 18-20 hours a day without eating. This is commonly known as time-restricted eating or intermittent fasting.

In rodent studies, a fasting routine was proven to be effective in reducing risk factors for age-related diseases. It lowered the risk of metabolic diseases such as cancer, diabetes, and obesity and increased cognitive ability. This is a simple hack that mimics the natural feeding/fasting cycles of our ancestors and allows the microbiome and immune system to function properly.

Please check with your physician before attempting extended fasts.


You’ve probably seen this yellow powder on the spice shelves or have even used it for its flavoring. Turmeric is the ground up version of the turmeric rhizome, a perennial plant that resembles a large orange ginger root. it has been used throughout human history for its health properties and has become a staple in any biohackers kitchen.

This is because turmeric contains a very important polyphenol called curcumin, a known antioxidant. This substance gives turmeric its vibrant color and also inhibits enzymes that mediate inflammatory processes, making it anti-inflammatory by nature.

To take the hack one step further, it’s recommended to use turmeric and black pepper together, as the piperine in the pepper enhances curcumin absorption into the body, making sure you’re getting the full bang for your buck. So sprinkle some turmeric and pepper on your salads, soups, or even smoothies to get the full benefits of this anti-inflammatory spice.

Omega 3

The inflammaging process is complicated and involves many mechanisms happening at once. Senescent cells build up, certain compounds are created to alert the immune system, and inflammation is the by-product.

Thankfully, studies have been conducted on the intricate cellular functions that cause this and it’s been found that Omega-3 (commonly supplemented as fish oil) changes the fatty acid composition of cells involved in the inflammatory response, having a positive effect on overall health.

You can get Omega-3 fatty acids by eating plenty of fish and flaxseed, or by supplementing orally. Always try to purchase supplements from a reputable company to ensure quality.

Inflammation is neither friend nor foe. It is a vital part of immunosurveillance and defense, yet can also be a symptom of chronic disease. When it occurs consistently due to poor gut health or inefficient autophagy, it serves as a risk factor for age-related diseases and is known as inflammaging,

By being proactive with your life choices- eating anti-inflammatory foods, incorporating fasting, and supplementing with turmeric and Omega-3, you can lower your inflammatory markers and have positive effects on your healthspan and day-to-day well-being.

At the Institute for Human Optimization, we take inflammaging seriously. Instead of waiting for the effects of chronic inflammation to present themselves, we encourage our patients to eat according to their genome and test for specific biomarkers for a personalized approach to healthcare.

The goal of functional medicine is to get to the root cause of disease. This almost always stems from purposeful prevention. Nothing manifests overnight. It is your everyday habits that create your healthspan, whether you see the effects or not. We give you a deep dive into what’s really happening in your body so you can make educated decisions to age well and live better.

Schedule a call to discuss how we can optimize your health.

To your longevity,

Anil Bajanth MD
CEO/Founder, Institute for Human Optimization
Chief Medical Advisor, Longevity Insider HQ

* Today's content is provided by the Institute for Human Optimization (